Journal: Annals of Translational Medicine
Article Title: Effect of roxadustat on serum metabolome and lipidome in patients with end-stage renal disease and erythropoiesis-stimulating agent resistance
doi: 10.21037/atm-22-4451
Figure Lengend Snippet: Bile acids changes during drug treatment. (A) Concentration ratios of significantly differential bile acids among the three groups; (B) pathways of bile acids. *P<0.05 and FDR <0.05 for drug-15 days compared with baseline; # P<0.05 and FDR <0.05 for drug-30 days compared with baseline. FDR, false discovery rate; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; GDCA, glycodeoxycholic acid; GLCA, glycolithocholic acid; GUDCA, glycoursodeoxycholic acid; LCA, lithocholic acid; TCA,taurocholic acid; TCDCA, taurochenodeoxycholicacid; TDCA, tauroursodeoxycholic acid; TLCA, taurolithocholic acid; TUDCA, tauroursodeoxycholic acid; UDCA, ursodeoxycholic acid.
Article Snippet: Carnitine (Car) C2:0-d3, Car C10:0-d3, Car C16:0-d3, phenylalanine-d5 (Phe-d5), tryptophan-d5 (Trp-d5), cholic acid-d4 (CA-d4), and chenodeoxycholic acid-d4 (CDCA-d4) were purchased from Sigma-Aldrich and used as the internal standards (IS) for metabolomic profiling.
Techniques: Concentration Assay